HHS Explores Lung-on-a-Chip Technology in Developing Chemical Injury Treatments
The U.S. Department of Health and Human Services (HHS) will support tests of organ-on-a-chip technology to determine how it can be used to understand injuries caused by inhaled chlorine gas, a potential national security threat, and to develop treatments for those injuries.
The Biomedical Advanced Research and Development Authority (BARDA), part of the HHS Office of the Assistant Secretary for Preparedness and Response, will provide technical expertise and approximately $13.5 million over the next two years to Wake Forest Institute for Regenerative Medicine (WFIRM) of Winston-Salem, North Carolina, to validate how the group’s lung-on-a-chip technology, also known as an organ tissue equivalent, works in modeling the effects of chlorine gas on human lungs. BARDA can support additional work over the next five years, providing funding up to a total of approximately $24 million.
“We are continually looking for disruptive technologies that accelerate the development of medical products to save lives in incidents involving some of the most horrific health security threats our country faces,” explained BARDA Director Rick Bright, Ph.D. “Organ-on-a-chip technology has the potential not only to inform our decisions about the most promising investigational products to pursue, but also to revolutionize the speed and cost-efficiency of developing those products.”
The lung-on-a-chip platform is part of WFIRM’s overall Body-on-a-Chip program, a miniaturized system of human organs that can be used to model the body’s response to harmful agents. To create the system, human cells are used to create tiny 3D organ-like structures called tissue equivalents that mimic the function of the heart, liver, lung, or blood vessels.
Placed on a two-inch chip, these structures are connected to a system of fluid channels and sensors to provide online monitoring of individual organs-on-a-chip and the overall system. Circulating a blood substitute keeps the cells alive and can be used to introduce chemical …read more
From:: CBRNe World (CBRN)